规格

价格

库存

数量

1 mg

¥ 166

现货

5 mg

¥ 335

现货

10 mg

¥ 517

现货

25 mg

¥ 928

现货

50 mg

¥ 1,610

现货

100 mg

¥ 2,690

现货

200 mg

¥ 3,960

现货

500 mg

¥ 6,260

现货

生物活性

产品描述	Plerixafor octahydrochloride (JM3100 octahydrochloride) blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation. Plerixafor is a bicyclam with hematopoietic stem cell-mobilizing activity.
靶点活性	HIV-2:1-10 nM (EC50), HIV-1:1-10 nM (EC50), CXCL12:5.7 nM, CXCR4:44 nM
体外活性	AMD 3100 能抑制初代T4淋巴细胞中低通道临床HIV-1分离株（K31、D370、K6/-2、HEM和JRCSF）的复制（EC50s：0.16-1.5 ng/ml；EC90s：0.36-4.7 ng/ml）。在初代单核细胞中，AMD 3100 对HIV-1（K31和SF-162）具有活性，其EC50s为0.28-7.2 ng/mL，EC90s为0.68-12 ng/mL。
体内活性	在通过皮下途径给予兔子AMD 3100（10 mg/kg）后，其血清中化合物浓度是通过基于该化合物对MT-4细胞中HIV-1细胞毒性抑制所需EC50的生物检测方法来确定的。
细胞实验	Plerixafor is dissolved in DMSO and then diluted with appropriate medium[2]. U87 mg cells are seeded in 96-well plates at the density of 6×103 cells in 200 μL/well and treated with CXCL12, Plerixafor or with peptide R, as described in the previous "Treatments" section. MTT (5 μg/mL) is added at each time point (24, 48, 72 h) during the final 2 h of treatment. After removing cell medium, 100 μL DMSO are added and optical densities measured at 595 nm with a LT-4000MS Microplate Reader. Measurements are made in triplicates from three independent experiments[2].
别名	盐酸普乐沙福, SID791 octahydrochloride, Plerixafor 8HCl (AMD3100 8HCl), Plerixafor 8HCl, JM3100 octahydrochloride, JM 3100 8HCl, AMD 3100 octahydrochloride

化学信息

分子量	794.46
分子式	C₂₈H₆₂Cl₈N₈
CAS No.	155148-31-5
Smiles	Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl.C(N1CCCNCCNCCCNCC1)c1ccc(CN2CCCNCCNCCCNCC2)cc1
密度	0.962g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: Insoluble

H2O: 242.5 mg/mL (305.24 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	1.2587 mL	6.2936 mL	12.5872 mL	62.9358 mL
5 mM	0.2517 mL	1.2587 mL	2.5174 mL	12.5872 mL
10 mM	0.1259 mL	0.6294 mL	1.2587 mL	6.2936 mL
20 mM	0.0629 mL	0.3147 mL	0.6294 mL	3.1468 mL
50 mM	0.0252 mL	0.1259 mL	0.2517 mL	1.2587 mL
100 mM	0.0126 mL	0.0629 mL	0.1259 mL	0.6294 mL